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Exome or Whole Genome Sequencing?

This is one of the most discussed topics especially in Clinical Genomics! Affordability, accuracy, feasibility and of course time consumption - based on these factor mostly, which sequencing technology is more suitable for clinics? Whole Exome Sequencing or Whole Genome Sequencing? (WGS or WES, WGS vs WES) So here's my 2 cents on this discussion! When it comes to DNA sequencing there has always been a raging debate over the choice of Whole Genome Sequencing (WGS) or Whole Exome Sequencing (WXS) for routine use. Whole genome sequencing (WGS), as the name suggests is the process of obtaining the entire genome. In most cases however, this is far from practical and only 95-97% of the genome is covered because it is technically difficult to sequence certain regions of the genome (high GC content, large repeat regions, centromeres, telomeres, etc.) with existing technology. “It’s very fair to say the human genome was never fully sequenced,”  - Craig Venter “The human genome ha...
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How do Dogs get rid of hiccups so quickly while most humans seem to struggle?

My dog is laying here on the couch and I noticed she just contracted hiccups and within 3 hiccups was back to normal again. Its not the first time I noticed, just the first time I noticed while browsing Quora.

Humans will go to the ends of the earth trying every homeopathic cure known or suggested and can struggle for a considerable length of time to rid themselves of them. 

The answer is in our anatomy.. our epiglottis is perpendicular to the axis of the trachea and is almost vertical due to our upright pose while it is slightly tilted in case of dogs!
Venkatesh Chellappa (BVSc. &AH, MSc.)

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  1. Unknown22 May 2018 at 15:03

    Thanks for every other informative site. The place else may just I get that kind of information written in such an ideal means? I have a venture that I’m just now operating on, and I have been on the look out for such information. do dogs have hiccups

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Exome or Whole Genome Sequencing?

This is one of the most discussed topics especially in Clinical Genomics! Affordability, accuracy, feasibility and of course time consumption - based on these factor mostly, which sequencing technology is more suitable for clinics? Whole Exome Sequencing or Whole Genome Sequencing? (WGS or WES, WGS vs WES) So here's my 2 cents on this discussion! When it comes to DNA sequencing there has always been a raging debate over the choice of Whole Genome Sequencing (WGS) or Whole Exome Sequencing (WXS) for routine use. Whole genome sequencing (WGS), as the name suggests is the process of obtaining the entire genome. In most cases however, this is far from practical and only 95-97% of the genome is covered because it is technically difficult to sequence certain regions of the genome (high GC content, large repeat regions, centromeres, telomeres, etc.) with existing technology. “It’s very fair to say the human genome was never fully sequenced,”  - Craig Venter “The human genome ha...
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Humble beginnings!

It all starts when you start running towards Biology in your high school, not because you love and live biology but mostly because you loathe mathematics. At least that would be the case with the majority of us. I find no need to confess here as I went on to become a Veterinarian.  I know my blog's name is Ramblings of a Bioinformatician and without the mathematical aptitude, it is futile to wish for specialization in this field (I would equate that to an Aston Martin Vantage with a Citroen C1 engine)! I do not loathe mathematics but somehow fell for this pernicious trend of calling oneself a 'math-person' and 'not-a-math-person'! This psychology and related humbuzz are explained in detail in this article -   "There’s one key difference between kids who excel at math and those who don’t". But then again, there was this unsettled feeling. Having spent those numerous one-hour slots in private internet browsing centres, having dismantled the as...
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